Yep, I've got Python 2.5.1, PyXML v0.8.4 and Python Imaging Library v1.1.6 installed (using binary installers).
If you use the above, the latest version of Blender you can use is 2.44 (2.5 being the newest on their site). If you go into their repository you can download 2.44; with which blender2crystal should work with the above components.