I don't know if this would be CS's job (maybe Freetype's?) but I think it'd be nifty if CS could do sub-pixel font rendering. It's not a big deal, but I think it looks really nice, and many people seem to use/have LCD screens now.
Just in case: http://grc.com/ctwhat.htm
(explanation of what SPFR is) and http://grc.com/cleartype.htm
(the general page that links to the previous link).